Magnetic nano-particles and their applications in immunoassay

Magnetic Nano-particles and Their Applications in Immunoassay

Journal: J. Soc. | Volume: 48 | Page: 999 | Year: 2006

Published: July 23, 2015 (Date: 2015.07.23)

Magnetic Nanoparticles Immunoassay Fe₃O₄ Biocompatible SQUID

Abstract

Biocompatible magnetic nano-particles show great potential in bio-magnetic applications, such as MRI contrast agents, drug delivery, magnetically labeled immunoassays, and so on.

In this work, the feasibility of magnetically labeled immunoassay using bio-compatible magnetic nano-particles is investigated. To do this, we study the synthesis technologies for magnetic nano-particles of Fe₃O₄, as well as the coating of various bio-probes onto the magnetic nano-particles to detect the bio-targets avidin, such as, etc.

Furthermore, different measurements, like magnetic relaxation and saturated magnetization, for the amounts of bio-targets are developed. In order to achieve an ultra-high sensitivity in magnetically labeled immunoassays, we used SQUIDs because SQUIDs are the most sensitive sensors for magnetic signals.

The characterizations of these magnetically labeled immunological measurements are discussed.

Research Focus

This research investigates the following aspects of magnetically labeled immunoassay:

• Synthesis Technologies: Study of synthesis methods for Fe₃O₄ magnetic nano-particles
• Bio-probe Coating: Coating various bio-probes onto magnetic nano-particles
• Bio-target Detection: Detection of bio-targets such as avidin
• Measurement Methods: Development of magnetic relaxation and saturated magnetization measurements
• SQUID Detection: Use of SQUIDs (most sensitive sensors for magnetic signals) for ultra-high sensitivity
• Characterization: Discussion of magnetically labeled immunological measurement characteristics

Potential Applications

According to the abstract, biocompatible magnetic nano-particles show great potential in the following bio-magnetic applications:

• MRI Contrast Agents: Enhancement of magnetic resonance imaging
• Drug Delivery: Targeted delivery of therapeutic agents
• Magnetically Labeled Immunoassays: Detection of bio-targets with magnetic labeling

Key Technical Elements

1. Magnetic Nano-particle Material

The study focuses on Fe₃O₄ (magnetite) magnetic nano-particles, which are biocompatible.

2. Bio-probe Coating

Various bio-probes are coated onto the magnetic nano-particles to enable detection of specific bio-targets.

3. Bio-target

The research specifically mentions avidin as a bio-target for detection.

4. Measurement Techniques

Two measurement approaches are developed:

• Magnetic Relaxation: Measurement of magnetic relaxation properties
• Saturated Magnetization: Measurement of saturated magnetization

5. Detection Sensitivity

To achieve ultra-high sensitivity, the study employs SQUIDs (Superconducting Quantum Interference Devices), which are described as the most sensitive sensors for magnetic signals.

Research Significance

This work investigates the feasibility of using biocompatible magnetic nano-particles for magnetically labeled immunoassay. The study addresses:

• Synthesis technologies for producing magnetic nano-particles
• Methods for coating bio-probes onto nanoparticles
• Techniques for detecting bio-targets
• Measurement approaches for quantifying bio-target amounts
• Achievement of ultra-high sensitivity through SQUID-based detection

The characterizations of these magnetically labeled immunological measurements provide insights into the practical application of this technology.

Authors

H.E. Horng

Chin-Yih Hong

S.Y. Yang

H.C. Yang

S.H. Liao

C.M. Liu

C.C. Wu

Published in: J. Soc.
Volume: 48 | Page: 999 | Year: 2006
Date: 2015.07.23

How to Cite This Article

H.E. Horng, Chin-Yih Hong, S.Y. Yang, H.C. Yang, S.H. Liao, C.M. Liu, and C.C. Wu, "Magnetic nano-particles and their applications in immunoassay", J. Soc., vol. 48, p. 999, 2006.

BibTeX:

@article{Horng2006,
  title={Magnetic nano-particles and their applications in immunoassay},
  author={Horng, H.E. and Hong, Chin-Yih and Yang, S.Y. and Yang, H.C. and Liao, S.H. and Liu, C.M. and Wu, C.C.},
  journal={J. Soc.},
  volume={48},
  pages={999},
  year={2006}
}

Keywords

Magnetic nano-particles • Immunoassay • Fe₃O₄ • Biocompatible • Bio-probes • Avidin • Magnetic relaxation • Saturated magnetization • SQUID • Ultra-high sensitivity • Bio-magnetic applications • MRI contrast agents • Drug delivery

Published in: J. Soc.

Volume: 48 | Page: 999 | Year: 2006

Article Date: 2015.07.23